DESIGN OF EXPERIMENT BASED STUDY OF FACTORS AFFECTING THE UV ABSORPTION OF ASPIRIN
Abstract
The degradation studies are essential for pharmaceutical products as they give information about the stability of pharmaceutical products under various stress conditions. The studies provide information about the degradation pathways and degradation products that could form during storage. Forced degradation studies may help facilitate pharmaceutical development as well in areas such as formulation development, manufacturing, and packaging, in which knowledge of chemical behavior can be used to improve a drug product. Acetylsalicylic acid, or aspirin, was introduced in the late 1890s and has been used to treat as a non-steroidal anti-inflammatory medication (NSAID) for treating minor aches and pains, it is also commonly found in wastewater effluent. Moreover, it is used as an antipyretic to reduce fever, as an anti-inflammatory drug, and to reduce the risk of mortality from a heart attack. For proper risk assessment of Aspirin and a better understanding of the factors involved in its environmental fate, different factors were studied that were involved in the degradation of aspirin. Effect on degradation was studied for three factors, i.e., time, temperature, and concentration of oxidant at three different levels using the Design of experiment (DoE) approach. Absorbance was selected as a response that would signify the extent of degradation of the drug. All three factors the concentration of oxidant, temperature, and time were involved in degradation.
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References
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