ANTIMICROBIAL POTENTIAL OF MEDICINAL PLANT EXTRACTS PREPARED BY DECOCTION AND PERCOLATION TECHNIQUES
Abstract
Background: The growing prevalence of multidrug-resistant pathogens necessitates novel therapeutic approaches, including the use of plant-derived bioactive compounds in combination with conventional antibiotics. Objective: This study investigates the extractive yields, antibacterial activity, and potential of Hibiscus sabdariffa, Syzygium aromaticum, and Thymus vulgaris using two extraction techniques—decoction and percolation. Material and Methods: Extractive yields were quantified, and in vitro antimicrobial activity was evaluated against Gram-positive (Bacillus cereus, Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella spp.) using agar well diffusion and disc diffusion methods. Results & Discussion: Decoction extracts showed moderate inhibition, while percolation extracts demonstrated superior activity, particularly against B. cereus, S. aureus, and P. aeruginosa. Studies revealed significant enhancement of antimicrobial efficacy when plant extracts were combined with Streptomycin or Fluconazole, particularly against resistant Gram-negative strains. Conclusion: These findings suggest that plant-antibiotic combinations represent a promising approach for combating antimicrobial resistance.
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