DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL PATCH OF TIMOLOL MALEATE

Abstract

The oral transmucosal Timolol maleate delivery bypasses liver and avoids presystemic elimination in the gastro intestinal tract and
liver which enhance the bioavailability as well decreases the adverse effect. Objective: The present investigation highlights the formulation and
evaluation of mucoadhesive buccal patch of Timolol maleate because Timolol maleate has biphasic solubility hence relatively permeated through
buccal mucosa, which is well supplied with both vascular and lymphatic drainage. Material and Method: The mucoadhesive buccal patches of
Timolol maleate were prepared by solvent casting technique using polymers like Hydroxypropylmethyl cellulose-15cps and Polyvinyl
pyrrolidone. The formulated films were evaluated for their physiochemical parameters like surface pH, percentage moisture absorption, swelling
percentage, thickness, folding endurance and drug content. In vitro permeation and in vitro release studies were performed with pH 6.8 phosphate
buffer solution. Result and Discussion: The patches exhibited controlled release for more than 12 h. The in vitro release data were fit to different
equations and kinetic models to explain release profiles. The kinetic models used were zero order, first order higuchi’s and peppa’s. The best
mucoadhesive performance and matrix controlled release was exhibited by the formulation CK2 (3 % HPMC and 1 % PVP). Conclusion: Good
results were obtained both in physico chemical characteristics and in vitro studies in formulation CK2. Hence the formulations of Timolol
maleate bioadhesive buccal patch is a promising one as the controlled drug delivery with improved bioavailability.